Cryostim therapy

What is local Cryostim Therapy

Localized cryostimulation is a pivotal cryotherapy technological advancement in treating arthritis and other musculoskeletal pain disorders and a game-changer in decreasing inflammation, oxidative stress, and pain and enhancing joint-muscle injury recovery.

Cryostim technology

We use the latest local cryostimulation technology, namely the Metrum Cryo-T Elephant. The Cryo-T Elephant device uses liquid nitrogen vapor. The gas temperature at the nozzle outlet can range from -120 to -196 degrees to reach the correct skin and tissue temperature between 2 and 7 degrees within 4 minutes. In addition, the Cryo-T Elephant has a unique safety feature: sensors are placed inside the application nozzle to allow for remote measurement, maintain the correct temperature, and ensure optimal physiological and therapeutic effects while avoiding overcooling and unwanted frostbite.

Cryostim therapy vs ice

Ice or an ice pack reduces inflammatory conditions such as swelling and acute localized pain. However, local ice does not elicit the same and desired physiological responses in the human body as local cryostimulation therapy.

How can cryostim therapy benefit you? 


Summary & Intro

Reach the desired cryogenic temperature within 4 minutes and produce great pain-relievinganti-inflammatory, and antioxidant effects, with subsequent enhanced healing capability and recovery of injured tissue and exercise-induced muscle damage. In addition, cold stress can produce neuroprotective effects and improve nerve injury recovery and regeneration by including up-regulation of cold shock proteins RBM3 (RNA binding motif 3). 

Decrease blood flow and pain signals

Induce thermoregulation to cause excitation of sympathetic adrenergic fibers, the initially wanted vasoconstriction and subsequent tissue ischemia below harmful levels, and decrease nerve conduction velocity in pain fibers.

Produce strong pain relief

Decrease painpain threshold, and increase tolerance by the pain gate theory and up-regulation and down-regulation of the respective gene expressions mechanisms. In addition, cold stress causes strong pain-relieving, anti-inflammatory, and endogenous antioxidant hormones to be released, including noradrenaline from the peripheral nerve endings and brainstem nuclei in the brain. Descending pain modulation mechanisms also contribute to substantial pain relief.

Increase blood supply by 4 times

After the initial significant vasoconstriction, the cold stress causes parasympathetic excitation and local hyperemia to enrich cells of the treated tissue with increased oxygen, enzymes, and nutrients to a much greater degree than under normal, balanced conditions. In addition, desired intensified metabolic processes and reduced joint and muscle soreness and tension result. The thermoregulation cold stress processes are safe and well tolerable by the human body.

Decrease inflammation and outcomes

Decrease inflammatory serum marker C-reactive protein and release pro-inflammatory cytokines, including interleukin-1tumor necrosis factor, and histamine. On the other hand, cold stress causes a remarkable higher production and release of the anti-inflammatory profile, including interleukin-6 and interleukin-10intercellular adhesion molecule-1, and prostaglandin E2.

The cold stress attenuates the aberrant inflammatory process, oedema formation, and subsequent arthrogenic muscle inhibition, limiting protein degradation. As a result, more movement occurs in the inflamed and painful joint and spine, with increased muscle flexibility and range of motion, increased active muscle power, and enhanced and facilitated physical therapy and rehabilitation.

Decrease oxidation and outcomes

Decrease oxidative stress and increase anti-oxidative buffering capacities similar to winter swimmers. The cold stress remarkably increases the total antioxidant status and total antioxidant index.

Cold stress increases the activity of antioxidant enzymes, including superoxide dismutase and glutathione peroxidase, and non-enzymatic antioxidants, including uric acid. In addition, an increase in free radical reactions and the production of reactive oxygen and nitrogen species result, with enhanced antioxidant responses and favourable compensatory adaption changes.

Inflammation link to muscle-joint pain disorders

Inflammation is a necessary protective defence mechanism of the human being against injury and infection. The inflammatory response function to localize and eliminate the harmful agent, protect the injured tissue from further damage, and remove damaged tissue components so that the body can heal itself.

Excessive and chronic inflammation and oxidative stress play a vital role in the pathophysiology (cause) of inflammatory joint diseases and other musculoskeletal pain disorders, including osteoporosisexercise-induced muscle soreness, and muscle damage.

Oxidative stress link to muscle-joint pain disorders

Free radicals are toxic by-products of oxygen metabolism that can cause severe damage to living cells and tissues in a process known as oxidative stress. In addition to increased and aberrant inflammation, oxidative stress plays a vital role in the pathophysiology of inflammatory joint diseases and other musculoskeletal pain disorders, including osteoporosis.

Vigorous exercise causes and contributes to aberrant oxidative stress and produces detrimental muscle tissue effects. An antioxidant can decrease the production of free radicals by inhibiting the oxidation of other molecules and providing protection to cells from the damaging effects of oxidation.


Inflammatory arthritis

Decrease pro-inflammatory tumour necrosis factor and interleukin-1 with decreased pain and disease activity, and improved functional outcomes in individuals suffering from active inflammatory joint disease, including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.

Produce long-term effects of decreasing pain and disease activity and improving functional outcomes in individuals with chronic inflammatory arthritis, including rheumatoid arthritis and ankylosing spondylitis.

Rheumatic and musculoskeletal conditions comprise over 150 diseases and progressive syndromes, which are amongst the most widespread painful and disabling pathologies across the globe. Among those with the most significant impact on society are osteoarthritis, a degenerative joint disease, and rheumatoid arthritis, a chronic inflammatory joint autoimmune disease.

These diseases, particularly osteoarthritis, can no longer be labelled “degenerative” diseases. Instead, growing evidence supports a role of inflammation, not only locally, in promoting damage to joints and bones, as well as joint-related functional deficits.

Degenerative joint disease

Decrease the frequency and degree of pain perception and the use of pain killers, improve the range of physical activity and well-being in osteoarthritis of the spine and peripheral joints. In addition, cold stress produces beneficial effects in sciatica and ankylosing spondylitis arthritis of the spine, confirmed by thermovision.

Although osteoarthritis has traditionally been considered one of the most devastating chronic conditions affecting the middle to the old-age world population, osteoarthritis in young, active, and athletic individuals is rapidly rising in the present times.

Rheumatoid arthritis

Equals two weeks of traditional rehabilitation and therapeutic modalities to reduce pain, disability, and disease activity, including kinesiotherapy, magneto-therapy, electrotherapy, ultrasound, and laser therapy. In addition, cold stress with kinesiotherapy is superior to conventional rehabilitation in reducing pain, disease activity, and improving locomotor (movement) function, with many longer-lasting effects.

Cold stress decreases pro-inflammatory tumour necrosis factor and increases anti-inflammatory interleukin-6 in individuals with rheumatoid arthritis.

Compared to 4 weeks of conventional physiotherapy, cold stress remarkably decreases histamine levels, a compound released by cells in response to injury and allergic and inflammatory reactions. Histamine plays a significant pro-inflammatory role in the pathogenesis of rheumatoid arthritis.

Ankylosing spondylitis

Decrease serum inflammatory markers, total oxidative status, and increase total antioxidant status. In addition, in comparison with kinesiotherapy, cold stress decreases pain twice as much, reduces disease activity, and improves functional outcomes and quality of life.

Cold stress with subsequent kinesiotherapy markedly improves spinal mobility in individuals suffering from ankylosing spondylitis.

The progression of ankylosing spondylitis can result in fusion of the axial skeleton and a marked loss of physical function and spinal mobility.

Slipped disc

Decrease pain and improve functional outcomes confirmed by Magnetic Resonance Imaging (MRI) in individuals with herniation intervertebral disc.

Lumbar intervertebral disc herniation is the most common reason working-age individuals undergo lumbar spine surgery. A slipped disc can lead to excruciating referred leg and arm pain.


Decrease pain and swellings, cause skeletal muscles to relax and increase muscle power and range of motion in individuals with symptomatic osteoporosis.

A low bone density results from altered bone resorption and formation homeostasis and bone turnoverosteoclast activity surpass osteoblast activity. Typically, there are no symptoms unless the condition progresses to osteoporosis. Symptoms of osteoporosis include back pain, loss of height, a stooped posture, and easily fractured bones.

That is to say, cold stress enhances normal and healthy bone turnover in osteopenia and osteoporosis, significantly decreasing the serum-bone turnover marker osteocalcin and increasing carboxyterminal cross-linked telopeptide of type I collagen. In addition, cold stress markedly increases remodelling osteoimmunological biomarkers osteoprotegerin and counteracts the altered osteoclast activity with decreased bone resorption and decreased osteolytic disease progression.

Oxidative stress plays a significant role in the pathogenesis of osteoporosis and serves as a critical aggravating factor for osteopenia, osteoporosis, and insufficiency fractures.

Antioxidant systems present in the human body prevent oxidative stress. Still, the antioxidant systems of humans alone may be ineffective to combat the aberrant oxidative stress. Antioxidant therapy can alleviate the adverse effects of oxidative stress in osteoporosis.

Cold stress can decrease oxidative stress and increase anti-oxidative buffering capacities in healthy individuals, especially those suffering from musculoskeletal pain diseases.

Significant pain disorders

Decrease pain and increase lower pain threshold in individuals suffering from myofascial pain syndrome and fibromyalgia and improve health-reported quality of life in individuals suffering from musculoskeletal-pain disorders. In addition, cold stress decreases pain and disability and increases functional outcomes in the frozen shoulder or adhesive capsulitis and migraine headaches.

Musculoskeletal disorders are often incorrectly and ineffectively diagnosed and managed in primary care.

Muscle-joint injury and athletic enhancement

Enhance muscle injury and damage recovery, enhance muscle strength performance recovery, decrease exercise-induced muscle damage and soreness, and decrease delayed onset muscle soreness (DOMS), especially in the highly active individual and more elite-level athlete.

One cold stress treatment can enhance muscle injury recovery time and decreases muscle soreness. In addition, cold stress enhance exercise-induced muscle damage recovery with increased strength and reduced pain versus infrared radiation and passive modalities.

Cold stress enhance recovery time in re-establishing homeostasis of serum muscle damage markers, including creatine phosphokinase, lactate dehydrogenase, and calcium. In addition, cold stress improves oxygen delivery in the working muscles, decreases muscle spasticity, and increases muscle flexibility and range of motion.

We offer unique
spinal manipulation & localized cryostimulation
combination therapy with simplified pricing

Inflammation & oxidative stress play a vital role in pain and healing mechanisms. However, too much inflammation and free radicals cause harmful effects on the human cells, resulting in pain and delaying healing and injury recovery. Repetitive postural straining-poor posture, overuse, and trauma to the spine are some of the causes and contributing factors.

Localized cryostim therapy restores the normal anti- and pro-inflammation and oxidation balance in the spine and surrounding muscle tissues. In addition, spinal manipulation therapy mechanically and physiologically restores movement and reduces pain.

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